Lexius Lynch

M.S. Data Science

Exploratory Analysis of Alzheimer’s Disease: Unraveling the complexities of single cell RNA sequence Data

Single-cell biology is a field that focuses on understanding human health and diseases at the cellular level, with a particular emphasis on precision medicine. Identifying specific cell types in major brain disorders is a critical area of research. However, the complex cellular architecture of the brain, which consists of a diverse set of cell types, makes it challenging to determine the primary pathological cell type for a particular disease. Recent studies have used single-cell RNA and expression-weighted cell type enrichment to identify specific neuronal cell types associated with brain disorders, such as Alzheimer’s disease. Sc-RNA is a powerful technology that allows the analysis of a large number of individual cells. These studies have revealed statistically significant enrichment of certain neuronal cell types in the context of these disorders, providing valuable insights into the differentially expressed genes as well as cell signaling pathways critical to the understanding of variants associated with brain diseases.